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Ivermectin is one of the drugs that showed a positive response in labs earlier this year for treating SARS CoV-2, the virus that causes COVID-19.
San Antonio doctor uses this medicine to treat COVID patients. "It prevents COVID from replicating," Dr. Hoan Pho said of Ivermetcin. "And it also decreases the viral load." "Using ivermectin so far has helped the patients get better and quicker and preventing them from getting pneumonia," he said. (from www.cbs19.tv / Published: 9:59 PM CST January 5, 2021)



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KENS-TV San Antonio logoSan Antonio doctor uses hair lice medicine to treat COVID-19 patients; FDA warns more testing is needed
As hospitalizations surge in Bexar County, one San Antonio doctor is using a head lice drug that he believes is keeping his COVID-19 patients from ending up in the hospital.
Ivermectin is considered to be a safe drug to treat different types of parasitic infections in humans and animals, including lice, but is not FDA-approved for other uses.
However, Dr. Hoan Pho said when ivermectin is combined with other drugs, this medicine is working to treat his patients who have contracted COVID-19.
The FDA recognizes ivermectin has shown some effectiveness in a laboratory setting, but additional testing is needed, as the results from trials are still limited, according to the agency's website.
What is ivermectin and what does FDA think about it as a possible COVID-19 treatment?
Pho specializes in internal medicine and cites a study suggesting that the anti-parasitic drug can kill the coronavirus within 48 hours in a lab setting.
"It prevents COVID from replicating," he said. "And it also decreases the viral load."
The drug is widely available and runs about $20. Within the last month, Dr. Pho started using the drug on his patients.
"About 50-60 patients, there is no hospitalization," he said. "Nobody has gotten sicker and has required oxygen to be hospitalized."
He said half those patients were over the age of 65. If a patient is sick with COVID, Pho prescribes ivermectin with a couple of other drugs and supplements. He does believe the key is ivermectin.
"Using all of these medicines, particularly the ivermectin, so far has helped the patients get better quicker and preventing them from getting pneumonia," he said.
Available publications were discussed based on the study types (in vitro,in vivo, emergency use in hospitals, and clinical trials). All available articles until 10 May 2020wereconsiderate eligible. All studies were discussed narratively. To build our discussion, previous studiesassessing the antiviral effect of ivermectin against other viruses and its action mechanisms were alsosearched and discussed.3.
In addition, ivermectin exerted inhibitory activities against several RNA viruses, such as West Nilevirus [21], Venezuelan equine encephalitis virus (VEEV) [22], and influenza [18]. This antiviral effectwas not only demonstrated against RNA viruses, but was also shown to be effective against a DNAvirus, pseudorabies virus (PRV), both in vitro and in vivo [29].Ivermectin binds importin (IMP)αarmadillo (ARM) repeat domain, which causes IMPαthermalinstability andα-helicity that prevents IMPα-IMPβ1 interaction [30].
The elimination half-life of ivermectin is approximately 24 h, although a previous study suggested that thedrug persisted for several months after a single dose of ivermectin [27]. Ivermectin is distributed widelythroughout the body, owing to its high lipid solubility, and binds strongly to plasma proteins, particularlyserum albumin, and is notably excreted in feces [25].
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In short, ivermectin affects the IMPα/β1recognition of viral and other proteins by preventing its formation or dissociating the heterodimer,which is crucial in the nuclear transport of viral proteins. As the replication cycle of the virus andthe inhibition of the host’s antiviral response occur in a manner dependent on the nuclear transportof viral proteins, targeting the transport process may be a feasible pharmacological approach fordealing with RNA viral infections [21,30,31].
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