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Ivermectin is one of the drugs that showed a positive response in labs earlier this year for treating SARS CoV-2, the virus that causes COVID-19.
San Antonio doctor uses this medicine to treat COVID patients. "It prevents COVID from replicating," Dr. Hoan Pho said of Ivermetcin. "And it also decreases the viral load." "Using ivermectin so far has helped the patients get better and quicker and preventing them from getting pneumonia," he said. (from www.cbs19.tv / Published: 9:59 PM CST January 5, 2021)



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KENS-TV San Antonio logoSan Antonio doctor uses hair lice medicine to treat COVID-19 patients; FDA warns more testing is needed
As hospitalizations surge in Bexar County, one San Antonio doctor is using a head lice drug that he believes is keeping his COVID-19 patients from ending up in the hospital.
Ivermectin is considered to be a safe drug to treat different types of parasitic infections in humans and animals, including lice, but is not FDA-approved for other uses.
However, Dr. Hoan Pho said when ivermectin is combined with other drugs, this medicine is working to treat his patients who have contracted COVID-19.
The FDA recognizes ivermectin has shown some effectiveness in a laboratory setting, but additional testing is needed, as the results from trials are still limited, according to the agency's website.
What is ivermectin and what does FDA think about it as a possible COVID-19 treatment?
Pho specializes in internal medicine and cites a study suggesting that the anti-parasitic drug can kill the coronavirus within 48 hours in a lab setting.
"It prevents COVID from replicating," he said. "And it also decreases the viral load."
The drug is widely available and runs about $20. Within the last month, Dr. Pho started using the drug on his patients.
"About 50-60 patients, there is no hospitalization," he said. "Nobody has gotten sicker and has required oxygen to be hospitalized."
He said half those patients were over the age of 65. If a patient is sick with COVID, Pho prescribes ivermectin with a couple of other drugs and supplements. He does believe the key is ivermectin.
"Using all of these medicines, particularly the ivermectin, so far has helped the patients get better quicker and preventing them from getting pneumonia," he said.
(a) To identify risk of Zika virus (ZIKV) infection in Asia; (b). To identify and characterize current circulating Zika virus (ZIKV) in Indonesia; (c). To advance our understanding of the prevalen ... [more]
Ivermectin is also able to dissociatethe IMPα/β1 heterodimer, which further inhibits NS5-IMPαinteraction within cells [30]. A significantincrease in the ratio of free IMPαto IMPα/β1 was observed when the IMPα/β1 heterodimer wasincubated with 12.5µM ivermectin, suggesting that ivermectin binds IMPαdirectly to impact the IMPαstructure, most likely within the ARM repeat domain [30].
Sci. Pharm. 2020,88, 36 2 of 8result in mild symptoms, such as cough, fatigue, and myalgia [4]; however, up to 20.3% of hospitalizedpatients require admission to the intensive care unit (ICU) [5]. The data suggest that dysregulation ofthe host immune response contributes to disease progression and severity [6].COVID-19 is a global threat to public health and no effective vaccines or pharmaceutical agentsagainst SARS-CoV-2 are available [1,4].
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In addition, ivermectin exerted inhibitory activities against several RNA viruses, such as West Nilevirus [21], Venezuelan equine encephalitis virus (VEEV) [22], and influenza [18]. This antiviral effectwas not only demonstrated against RNA viruses, but was also shown to be effective against a DNAvirus, pseudorabies virus (PRV), both in vitro and in vivo [29].Ivermectin binds importin (IMP)αarmadillo (ARM) repeat domain, which causes IMPαthermalinstability andα-helicity that prevents IMPα-IMPβ1 interaction [30]. buy ivermectin for guinea pigs australia
Apart from differences in transmission and mortality rate, there are a lot of similarities in genetics, pathogenesis, clinical manifestation, etc. between SARS-CoV, MERS- Cov and SARS-CoV-2. Previous valuable lessons learned from other coronavirus outbreaks and a plethora of research data on this topic can help us to select the best treatment strategy for managing the 2020 pandemic. Taken ... [Show full abstract]View full-text buy ivermectin for dogs uk
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A previous study suggested an antagonistic effect of ivermectin on vitamin K after hematomatousswellings were reported in two out of 28 ivermectin-treated patients, along with a significantly increasedprothrombin time of between 1 week and 1 month after drug administration [28]. Notably, even thoughthe reduction of factor II and factor VII levels was reported to occur in most of the patients, bleedingcomplications were not observed in any patients [28].
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